Isolation of Antimalarial Agents From Indonesian Medicinal Plants: <i>Swietenia mahagoni</i> and <i>Pluchea indica</i>-Reference-Cited by-同舟云学术

Isolation of Antimalarial Agents From Indonesian Medicinal Plants: Swietenia mahagoni and Pluchea indica

Published:2022-01 Issue:1 Volume:17 Page:1934578X2110689
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Nugraha Ari S.¹²³^ORCID,Purnomo Yoshinta D.¹^ORCID,Widhi Pratama Antonius N.¹,Triatmoko Bawon¹^ORCID,Hendra Rudi⁴^ORCID,Wongso Hendris²³⁵^ORCID,Avery Vicky M.⁶⁷,Keller Paul A.²³^ORCID

Affiliation:

1. Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jember, Indonesia

2. School of Chemistry & Molecular Bioscience and Molecular Horizons, University of Wollongong,Wollongong, NSW, Australia

3. Illawarra Health & Medical Research Institute, Wollongong, NSW, Australia

4. School of Chemistry, University of Riau, Riau, Indonesia

5. Center for Applied Nuclear Science and Technology, National Nuclear Energy Agency, Bandung, Indonesia

6. Discovery Biology, Griffith University, Brisbane, QLD, Australia

7. School of Environment and Science, Griffith University, Brisbane, QLD, Australia

Abstract

Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial lead compounds to combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into the Indonesian medicinal plants Swietenia mahagoni and Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated 34,5-tri- O-caffeoylquinic acid (4) to be the most active against Plasmodium falciparum 3D7 and Dd2 strains with IC50 values of 8.2 and 8.8 µM, respectively. No cytotoxicity was observed against Human Embryonic Kidney cells at a concentration of 40 µM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X211068926

Reference29 articles.

1. Malaria elimination in Indonesia: halfway there

2. Spread of a single multidrug resistant malaria parasite lineage ( PfPailin ) to Vietnam

3. Malaria Distribution, Prevalence, Drug Resistance and Control in Indonesia

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