Sawtehtetronenin from Goniothalamus sawtehii and its Cytotoxicity-Reference-Cited by-同舟云学术

Sawtehtetronenin from Goniothalamus sawtehii and its Cytotoxicity

Published:2014-12 Issue:12 Volume:9 Page:1934578X1400901
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Thiplueang Chiarpha¹,Punyanitya Sittiporn²,Banjerdpongchai Ratana³,Wudtiwai Benjawan³,Udomputtimekakul Phansuang¹,Buayairaksa Mongkol⁴,Nuntasaen Narong⁵,Pompimon Wilart¹

Affiliation:

1. Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, 52100 Lampang, Thailand

2. Science and Technology Research Institute, Chiang Mai University, 53000 Chiang Mai, Thailand

3. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, 52000 Chiang Mai, Thailand

4. Department of Chemistry, Faculty of Science, Khon Kaen University, 40002 Khon Kaen, Thailand

5. The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, 10900 Bangkok, Thailand

Abstract

A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetronenin was found to be cytotoxic to human hepatocellular carcinoma HepG2 and breast cancer MDA-MB231 cells with IC50 values of 79.3+11.9 μM and 108.1+1.5 μM, respectively. Compound 1 was less toxic to both cell lines when compared with camptothecin, a chemotherapeutic drug.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400901228

Reference11 articles.

1. HillA.W. (1927) Bulletin of Miscellaneous Information. His Majesty's Stationery Office, London, 203.

2. Gigantetronenin and Gigantrionenin: Novel Cytotoxic Acetogenins from Goniothalamus giganteus

3. Gonionenin: A New Cytotoxic Annonaceous Acetogenin from Goniothalamus giganteus and the Conversion of Mono-THF Acetogenins to Bis-THF Acetogenins

4. cis -Gigantrionenin and 4-acetyl gigantetrocin A, two new bioactive annonaceous acetogenins from Goniothalamus giganteus , and the stereochemistries of acetogenin 1,2,5-triols

5. Gigantransenins A, B, and C, novel mono-THF acetogenins bearing trans double bonds, from Goniothalamus giganteus (Annonaceae)