Two New Antimicrobial Metabolites from the Endophytic Fungus, Seimatosporium sp-Reference-Cited by-同舟云学术

Two New Antimicrobial Metabolites from the Endophytic Fungus, Seimatosporium sp

Published:2012-03 Issue:3 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hussain Hidayat¹²,Krohn Karsten¹,Schulz Barbara³,Draeger Siegfried³,Nazir Mamona⁴,Saleem Muhammad⁴

Affiliation:

1. Department Chemie, Universität Paderborn, Warburger Straße 100, 33098 Paderborn, Germany

2. Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Sultanate of Oman

3. Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 31806 Braunschweig, Germany

4. Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan

Abstract

Two new acaranoic acids, named seimatoporic acid A and B (1, and 2), together with six known compounds, R-(-)-mellein (3), cis-4-hydroxymellein (4), trans-4-hydroxymellein (5), 4R-hydroxy-5-methylmellein (6), (-)-5-hydroxymethylmellein (7), and ergosterol (8) were isolated from an endophytic fungus, Seimatosporium sp, by a bioassay-guided procedure. The structures of the new compounds have been assigned from analysis of the 1H and 13C NMR spectra, DEPT, and by 2D COSY, HMQC, HMBC and NOESY experiments. A mixture of compounds 1 and 2 showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700305

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