Chemical Composition and Anti-Proliferative Properties of Bursera graveolens Essential Oil-Reference-Cited by-同舟云学术

Chemical Composition and Anti-Proliferative Properties of Bursera graveolens Essential Oil

Published:2012-11 Issue:11 Volume:7 Page:1934578X1200701
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Monzote Lianet¹,Hill Gabrielle M.²,Cuellar Armando³,Scull Ramón³,Setzer William N.²

Affiliation:

1. Institute of Medicine Tropical “Pedro Kourí”, Havana City, Cuba

2. Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

3. Institute of Pharmacy and Food, Havana City, Cuba

Abstract

Bursera graveolens is a wild tree of commercial importance native to the Neotropics, which has been widely used in folk medicine. In the present study, the chemical composition and anti-proliferative properties of the essential oil from B. graveolens were assayed. The chemical composition of the essential oil, determined by GC-MS, was complex and dominated by limonene (26.5%). Bursera oil inhibited the growth of MCF-7 breast tumor cells as well as amastigotes of L. amazonensis, with IC50 values of 48.9 ± 4.3 and 36.7 ± 4.7 μg/mL, respectively. In addition, the cytotoxicity of the oil was 103.9 ± 7.2 μg/mL against peritoneal macrophages from BALB/c mice. These results demonstrate that the essential oil from B. graveolens is a promissory antiproliferative product.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200701130

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