Affiliation:
1. Department of Pharmacy, University “G. D'Annunzio” of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy
Abstract
The direct synthesis of N3 substituted pyrimidine nucleoterpenes from uridine, thymidine, and inosine with C5, C10, and C15 side chains and using DBU as the base is described. In all cases the reaction proceeded smoothly in very good yields (85–99%) affording selectively N3 substituted adducts.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine