Ascidian Tunicate Extracts Attenuate Rheumatoid Arthritis in a Collagen-induced Murine Model-Reference-Cited by-同舟云学术

Ascidian Tunicate Extracts Attenuate Rheumatoid Arthritis in a Collagen-induced Murine Model

Published:2014-06 Issue:6 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hong Seong-Ho¹,Kwon Jung-Taek²,Lee Jae-Ho¹,Lee Somin¹³,Lee Ah Young¹,Cho Won-Young¹³,Bat-Erdene Munkhjargal⁴,Choi Byeong-Dae⁴,Cho Myung-Haing¹⁵³⁶

Affiliation:

1. Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151–921, Korea

2. Environmental Health Research Department, National Institute of Environmental Research, Incheon 404–708, Korea

3. Graduate Group of Tumor Biology, Seoul National University, Seoul, 151–742, Korea

4. Department of Seafood Science and Technology/The Institute of Marine Industry, Gyeongsang National University, 445 Inpyeong-dong, Tondyeong 650–160, Korea

5. Graduate School of Convergence Science and Technology, Seoul National University, Suwon 443–270, Korea

6. Advanced Institute of Convergence Technology, Seoul National University, Suwon 443–270, Korea

Abstract

Murine rheumatoid arthritis models are often used to investigate the potential therapeutic effects of candidate drugs. The present study has been conducted in order to investigate the therapeutic efficacy of ascidian tunicate extracts in a collagen-induced arthritis DBA1/J mice model. Four types of formulas, ascidian tunicate extracts (ATE), crude ascidian tunicate glycans (ATEC), ascidian tunicate extracts with licorice extracts (ATEL), and crude ascidian tunicate glycans with licorice extracts (ATECL) were orally administered into DBA/1J mice for 3 weeks and paw edema and thickness were evaluated. Changes in inflammatory proteins and cytokines levels were monitored in hind leg tissues by Western blot and quantitative PCR analysis. The oral administration of ascidian tunicate extracts alleviated paw edema and improved the histological hind leg cartilage status. The extracts also reduced the matrix metalloproteinase-9 (MMP-9) protein and prostaglandin E synthase (PGES) levels. In addition, the extracts-treated groups showed increased interleukin-10 (IL-10) levels compared with the non-treated group. These findings suggest that orally administered ascidian tunicate extracts might have potential therapeutic effects for the treatment of rheumatoid arthritis.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900632

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