Methyl Carnosate, an Antibacterial Diterpene Isolated from Salvia officinalis Leaves

Author:

Climati Elisa1,Mastrogiovanni Fabio1,Valeri Maria1,Salvini Laura2,Bonechi Claudia3,Mamadalieva Nilufar Zokirzhonovna4,Egamberdieva Dilfuza5,Taddei Anna Rita1,Tiezzi Antonio1

Affiliation:

1. Department for the Innovation in Biological, Agro-food and Forest systems, Laboratory of Plant Cytology and Biotechnology, Tuscia University, Largo dell'Università blocco D, 01100 Viterbo, Italy

2. Toscana Life Sciences, Via Fiorentina 1, 53100 Siena, Italy

3. Department of Pharmaceutical and Applied Chemistry, University of Siena, Via A. Moro 2, 53100 Siena, Italy

4. Institute of the Chemistry of Plant Substances, Mirzo Ulugbek Str 77, Tashkent 100170, Uzbekistan

5. Department of Biotechnology and Microbiology, National University of Uzbekistan, Tashkent 100174, Uzbekistan

Abstract

Ethanolic extracts of Salvia officinalis leaves demonstrated antibacterial activity against Bacillus cereus. Fractionation of the extracts led to the isolation of the most active antibacterial compound, which, from spectroscopic and LC-MS evidence, was proved to be the diterpene, methyl carnosate.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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