Major Constituents of the Predominant Endophytic Fungi from the Nigerian Plants Bryophyllum Pinnatum, Morinda Lucida and Jathropha Gossypiifolia-Reference-Cited by-同舟云学术

Major Constituents of the Predominant Endophytic Fungi from the Nigerian Plants Bryophyllum Pinnatum, Morinda Lucida and Jathropha Gossypiifolia

Published:2008-08 Issue:8 Volume:3 Page:1934578X0800300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Sowemimo Abimbola A.¹²,Edrada-Ebel RuAngelie³,Ebel Rainer⁴,Proksch Peter²,Omobuwajo Olanrewaju R.⁵,Adesanya Saburi A.⁵

Affiliation:

1. Department of Pharmacognosy, University of Lagos, Nigeria

2. Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Düsseldorf, Germany

3. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK

4. Department of Chemistry, University of Aberdeen, Aberdeen, UK

5. Department of Pharmacognosy, Obafemi Awolowo University, Ile-Ife, Nigeria

Abstract

In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3 R,4 R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0800300802

Reference33 articles.

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5. Diversity of endophytic fungal community of cacao (Theobroma cacao L.) and biological control of Crinipellis perniciosa, causal agent of Witches' Broom Disease

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