(-)-Sclerotiorin from an Unidentified Marine Fungus as an Anti-meiotic and Antifungal Agent-Reference-Cited by-同舟云学术

(-)-Sclerotiorin from an Unidentified Marine Fungus as an Anti-meiotic and Antifungal Agent

Published:2010-11 Issue:11 Volume:5 Page:1934578X1000501
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Bao Li¹,Xu Zhenyu²,Niu Shu-bin¹,Namikoshi Michio³,Kobayashi Hisayoshi⁴,Liu Hong-wei¹

Affiliation:

1. Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, 13 Beiertiao, Zhongguancun, Beijing 100080, PR China

2. Center for Drug Evaluation, SFDA, 1 Fuxing Road, Beijing 100038, PR China

3. Department of Natural Product Chemistry, Tohoku Pharmaceutical University 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

4. Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-32, Japan

Abstract

(-)-Sclerotiorin, isolated and purified from the fermented broth of an unidentified marine fungus (98F134), inhibited the maturation of starfish oocytes induced by 1-methyl adenine with an IC50 value of 0.50 μM. (-)-Sclerotiorin also showed antifungal activity against Saccharomyces Cerevisiae, Aspergilus Fumigatus, Alternaria Longipes, Piricularia Oryzae, Verticillium Albo-Atrum, Fusarium Culmorum, and F. nivale with IC50 values less than 20 μg/mL.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1000501119

Reference19 articles.

1. Drugs from the seas - current status and microbiological implications

2. Marine-derived fungi: a chemically and biologically diverse group of microorganisms

3. Isolation and Identification of Meiosis Inducing Substance in Starfish Asterias amurensis

4. Activation of Maturation Promoting Factor and 26S Proteasome Assembly Accelerated by a High Concentration of 1-Methyladenine in Starfish Oocytes

5. Cytoplasmic factor responsible for germinal vesicle breakdown and meiotic maturation in starfish oocyte