Identification and Modulatory Activity Assessment of 2-Hydroxy-3,4,6-trimethoxyacetophenone Isolated from Croton anisodontus Mull. Arg.(Euphorbiaceae)-Reference-Cited by-同舟云学术

Identification and Modulatory Activity Assessment of 2-Hydroxy-3,4,6-trimethoxyacetophenone Isolated from Croton anisodontus Mull. Arg.(Euphorbiaceae)

Published:2014-05 Issue:5 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Oliveira Maria T. A.¹,Teixeira Alexandre M R.¹,Coutinho Henrique D. M.¹,Menezes Irwin R. A.¹,Sena Diniz M.¹,Santos Hélcio S.²,de Mesquita Bruna M²,Albuquerque Maria R. J. R.²,Bandeira Paulo N.²,Braz-Filho Raimundo³

Affiliation:

1. Universidade Regional do Cariri, Crato, CE, Brazil, 63100-000

2. Universidade Estadual Vale do Acaraú, Sobral, CE, Brazil, 62040-370

3. Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil, 28013-600

Abstract

The n-hexane extract of the stem bark of Croton anisodontus yielded 2-hydroxy-3,4,6-trimethoxyacetophenone, a well-known substance, but isolated from this species for the first time. The antimicrobial and modulatory activities of the compound towards Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, C krusei and C tropicalis strains were assessed. Antibiotics such as amikacin, gentamicin and neomycin were used in a subinhibitory concentration. Significant activity was observed towards P. aeruginosa and S. aureus 358, with p < 0.001 in association with amikacin. The present results place C anisodontus as an alternative source of 2-hydroxy-3,4,6-trimethoxyacetophenone with antibacterial potential.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900520

Reference33 articles.

1. Diterpenos casbanos e acetofenonas de Croton nepetaefolius (Euphorbiaceae)

2. Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae)

3. Cytotoxic Diterpenoids from Croton argyrophylloides

4. Alkaloids and Diterpenes FromCroton moritibensis

5. Geographic Distribution of Three Alkaloid Chemotypes of Croton lechleri