A New Nervogenic Acid Glycoside with Pro-coagulant Activity from Liparis Nervosa-Reference-Cited by-同舟云学术

A New Nervogenic Acid Glycoside with Pro-coagulant Activity from Liparis Nervosa

Published:2013-08 Issue:8 Volume:8 Page:1934578X1300800
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Song Qin¹,Shou Qingyao²,Gou Xiaojun¹,Chen Fengzhen¹,Leng Jing³,Yang Weifeng⁴

Affiliation:

1. College of Biological Industry, Chengdu University, Chengdu 610106, P.R. China

2. Southern Cross Plant Science, Southern Cross University, PO Box 157, Lismore NSW 2480, Australia

3. Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, P.R. China

4. Hubei University of Chinese Medicine, Wuhan 430065, P.R. China

Abstract

In an effort to identify hemostatic components from Liparis nervosa (Thunb.) Lindl. using a bioactivity-guided fractionation approach, the n-BuOH extract was found to promote ADP-induced platelet aggregation and two compounds were isolated from the active extract. Compound 1 was a new nervogenic acid glycoside and the structure was elucidated as 3,5-bis(3-methyl-but-2-enyl)-4- O-[β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl]-benzoic acid by extensive spectroscopic measurements. Adenosine (2) was isolated from this plant for the first time. Compound 1 also showed good pro-coagulant activity in vitro.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800821

Reference4 articles.

1. Chemotaxonomical alkaloid studies I. Structure of nervosine

2. A New Monodesmosidic Triterpenoid Saponin from the Leaves of Pometia Pinnata

3. BrownB.A. (1988) Haematology: Principles and Procedures, fifth ed. Lea and Febiger, Philadelphia, 195–215.

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