New Cycloartane-type Triterpenes from Marcetia Latifolia (Melastomataceae) and In Silico Studies on Candida Parapsilosis Protease-Reference-Cited by-同舟云学术

New Cycloartane-type Triterpenes from Marcetia Latifolia (Melastomataceae) and In Silico Studies on Candida Parapsilosis Protease

Published:2013-08 Issue:8 Volume:8 Page:1934578X1300800
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Leite Tonny C. C.¹,Leite Franco H. A.¹,Vieira Ivo J. C.²,Filho Raimundo Braz²,Branco Alexsandro¹

Affiliation:

1. Departamento de Saúde, Universidade Estadual de Feira de Santana, Campus Universitário, Av. Transnordestina, s/n°, Bairro Novo Horizonte, 44.036–900, Feira de Santana, Bahia, Brazil

2. Setor de Química de Produtos Naturais-LCQUI-CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, 28013–602, Campos dos Goytacazes, Rio de Janeiro, Brazil

Abstract

We have previously reported the antimicrobial activity of the ethyl acetate extract of Marcetia latifolia, particularly against Candida parapsilosis. In this work we describe the isolation of two new cycloartane-type triterpenes, 28,29- bis-norcycloartan-3β,4α-diol (1) and 28,29- bis-norcycloart-24-en-3β,4α-diol (2) from the same extract. These compounds were mainly characterized by one- (1H, 13C and APT) and two-dimensional (1H-1H-COSY, 1H-1H-NOESY, HMQC and HMBC) NMR spectroscopy, mass spectrometry and comparison with published structural data. In addition, the activity of triterpenes 1 and 2 on the Candida protease target was investigated by in silico methods using molecular docking.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800804

Reference22 articles.

1. New hopane triterpene from Eleocharis sellowiana (Cyperaceae)

2. Anti-inflammatory Triterpenes from the Leaves of Rosa laevigata

3. In vivo Analgesic and Anti-Inflammatory Activities of Ursolic Acid and Oleanoic Acid from Miconia albicans (Melastomataceae)

4. Evaluation of the analgesic activity of extracts of Miconia rubiginosa (Melastomataceae)