Antialcohol Effects of Dihydromyricetin in Combination With Other Flavonoids

Abstract

Herbal remedies are consumed by approximately 50% of the population in the United States for health and wellness, including products promoted for liver health and alcohol (ethanol [EtOH]). Previously, we have shown that dihydromyricetin (DHM), a bioflavonoid, can counteract EtOH intoxication and withdrawal via GABAA receptor (GABAAR) activity. Through evaluation of GABAAR potentiation using DHM, resveratrol, genistein, daidzein, and turmeric, we found that the activity of DHM is unique. Furthermore, using the loss of right reflex induced by EtOH in rats, we discovered that DHM was superior in reducing EtOH intoxication and EtOH actions on GABAARs. However, the combination of DHM with turmeric, daidzein, or resveratrol diminished the DHM effects. Here, we report that combinations of DHM should be evaluated, as we have found that combining DHM with other flavonoids diminished efficacy. Collectively, these data support the utility of DHM as a unique antialcohol intoxication therapy.