Alkaloids From Zanthoxylum nitidum and Their Cytotoxic Activity-Reference-Cited by-同舟云学术

Alkaloids From Zanthoxylum nitidum and Their Cytotoxic Activity

Published:2019-05 Issue:5 Volume:14 Page:1934578X1984413
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Nguyen Thi Hong Van¹,Tran Thi Tuyen¹,Cam Thi Inh¹,Pham Minh Quan¹,Pham Quoc Long¹,Vu Dinh Hoang²,Nguyen Xuan Nhiem³,Chau Van Minh³,Van Kiem Phan³⁴

Affiliation:

1. Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam

2. Hanoi University of Science and Technology, Hai Ba Trung, Hanoi, Vietnam

3. Institute of Marine Biochemistry, VAST, Cau Giay, Hanoi, Vietnam

4. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Abstract

Zanthoxylum nitidum (Roxb.) DC (Rutaceae) is a traditional medicine used for the treatment of various diseases like toothache, gingivitis, fever, colic vomiting, diarrhea, and cholera. Three new alkaloids, zanthocadinanine C (1), 7-methoxy-8-demethoxynitidine (2), and zanthonitiside I (3) were isolated from the stems and twigs of Z. nitidum. Their structures were determined on the basis of extensive spectroscopic, including 1-dimensional and 2-dimensional nuclear magnetic resonance and mass spectroscopy data. Compounds 1–3 were evaluated for cytotoxic activity against 5 human cancer cell lines, KB, MCF-7, LNCaP, HepG-2, and LU-1. Compound 2 showed significant cytotoxic activity against all tested human cancer cell lines with IC50 values ranging from 10.3 to 12.6 µM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X19844133

Reference14 articles.

1. Two New Benzophenanthridine Alkaloids fromZanthoxylum nitidum

2. Benzophenanthridine Alkaloids fromZanthoxylum nitidum (Roxb.) DC, and Their Analgesic and Anti-Inflammatory Activities

3. Dihydrobenzo[c]phenanthridine Alkaloids from Stem Bark of Zanthoxylum nitidum

4. Secondary Metabolites and Cytotoxic Activities from the Stem Bark ofZanthoxylum nitidum

5. Studies on the Chemical Constituents of Xanthoxylum nitidum (Roxb.) D. C. (Fagara nitida Roxb.). III. The Chemical Constituents of the Wood.

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