5α,8α-Epidioxysterols from a Formosan Sponge, Axinyssa sp-Reference-Cited by-同舟云学术

5α,8α-Epidioxysterols from a Formosan Sponge, Axinyssa sp

Published:2013-11 Issue:11 Volume:8 Page:1934578X1300801
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Su Tzu-Rong¹,Liang Kai-Ju²³,Chiang Michael Y.⁴,Lu Mei-Chin²³,Wu Yu-Jen⁵,Su Jui-Hsin²³

Affiliation:

1. Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan

2. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan

3. Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan

4. Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan

5. Department of Beauty Science, Meiho University, Pingtung 912, Taiwan

Abstract

One new 5α,8α-epidioxysterol, 3-acetylaxinysterol (1), along with one known sterol, axinysterol (2), were isolated from a Formosan sponge, Axinyssa sp.. The structures of the compounds were determined by spectroscopic methods and the absolute configuration of 2 was further confirmed by single-crystal X-ray diffraction analysis for the first time. Compound 2 exhibited significant cytotoxicity against K562 and Molt 4 cancer cell lines.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300801108

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