A New Flavone Glycoside From Lumnitzera littorea with In Vitro α-Glucosidase Inhibitory Activity

Author:

Thuy Nguyen T. L.1,Thuy Pham T.2,Tung Bui T.1,Loc Huynh T.1,Dang Truong T. T.1,Ngoc Le L.1,Duc Nguyen X.2,Dung Le T.1,Hansen Poul E.3,Phung Nguyen K. P.2

Affiliation:

1. Department of BioTechnology, Ho Chi Minh City Open University, Vietnam

2. Department of Organic Chemistry, University of Science, National University – Ho Chi Minh City, Vietnam

3. Department of Scienceand Environment, Roskilde University, Denmark

Abstract

A new flavone glycoside, lumnitzerone (1), was isolated from leaves of Lumnitzera littorea, together with 9 known flavonoids. Their structures were elucidated by spectroscopic (one-dimensional, two-dimensional nuclear magnetic resonance) and high-resolution mass spectrometry analysis, and comparison with literature data. Extracts and all isolated compounds were evaluated for α-glucosidase inhibitory activity; all the extracts and most of the isolated compounds exhibited better activities than the positive control acarbose.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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