Two New Geranylated Biphenyl Esters From Artocarpus altilis

Abstract

Two new geranylated biphenyl esters, 2,3′,4,4′-tetrahydroxy-3-geranyl-5-carboxyethyl-biphenyl methyl ester (1), 2,3′,4,4′-tetrahydroxy-3-geranyl-5-carboxymethyl-biphenyl methyl ester (2), together with 4 known compounds were isolated from the methanol extract of the leaves of Artocarpus altilis. Their structures were established by spectroscopic means and by comparison with literature data. Compound 1 possessed moderate cytotoxicity toward MDA-MB-231 (a breast carcinoma cell line) with a half-maximal inhibitory concentration value of 30 µM and inhibited the growth of 8 bacteria, including gram-negative and gram-positive organisms, but was inactive against fungi.