Two New Morphinandienone Alkaloids from Croton micradenus

Author:

Payo-Hill Armando L.1,Sandoval-López Daysi1,Vélez-Castro Hermán T.2,Spengler-Salabarría Iraida3,Rastrelli Luca4

Affiliation:

1. Instituto de Ecología y Sistemática, CITMA, Carr. Varona Km. 3 1/2, A.P. 8010, Boyeros, C. Habana, Cuba

2. Centro de Química Farmacéutica, MINSAP, 200 y 21, Atabey, C. Habana, Cuba

3. Laboratorio de Productos Naturales, MES, Zapata y G, Vedado, C. Habana, Cuba

4. Dipartimento di Farmacia, University of Salerno, Via Ponte don Melillo, 84084 Fisciano (SA), Italy

Abstract

Two new 8,14-dihydromorphinandienone alkaloids were isolated from the dried leaves of Croton micradenus. Spectroscopic analysis established their structures as trans B/C-4-hydroxy-3,6-dimethoxy-5,6-didehydromorphinan-7-one and cis B/C-4-hydroxy-3,6-dimethoxy-5,6-didehydromorphinan-7-one to which we have given the name of norocobotrine and nildahilline.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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