Aconitamide, a Novel Alkaloid from the Roots of Aconitum carmichaeli-Reference-Cited by-同舟云学术

Aconitamide, a Novel Alkaloid from the Roots of Aconitum carmichaeli

Published:2013-06 Issue:6 Volume:8 Page:1934578X1300800
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Lee Tzong-Huei¹,Chen Yu-Chang²,Lee Ching-Kuo³,Chang Hsun-Shuo⁴,Kuo Ching-Chuan⁵,Chao Che-Yi⁶,Lin Jing-Jer⁷,Lo Lee-Chiang⁸,Kuo Yueh-Hsiung⁹

Affiliation:

1. Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan

2. Department of Chinese Pharmaceutical Sciences and Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan

3. School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan

4. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan

5. National Institute of Cancer Research, National Health Research Institutes, Tainan 707, Taiwan

6. Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan

7. Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan

8. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

9. Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan

Abstract

Aconitum carmichaeli Debx. is a traditional Chinese medicine commonly employed for curing a wide array of diseases in East Asia. From the ethyl acetate soluble fraction of the methanolic extracts of A carmichaeli, a new alkaloid, aconitamide (1), along with eighteen known compounds 2–19 were isolated by column chromatography and identified on the basis of spectroscopic analyses. The anti-telomerase activity of 1–19 was also assessed, but no activity was found, even at a concentration higher than 30 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300800637

Reference5 articles.

1. The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats

2. Alkaloids of Chinese Aconitum plants

3. Amides and an Alkaloid from Portulaca oleracea

4. A Novel Carbazole Derivative, BMVC: a Potential Antitumor Agent and Fluorescence Marker of Cancer Cells

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3. A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux;Journal of Ethnopharmacology;2015-02