Extraction Methods Play a Critical Role in Chemical Profile and Biological Activities of Black Cohosh-Reference-Cited by-同舟云学术

Extraction Methods Play a Critical Role in Chemical Profile and Biological Activities of Black Cohosh

Published:2008-09 Issue:9 Volume:3 Page:1934578X0800300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Jiang Bei¹²,Reynertson Kurt A.²,Keller Amy C.²,Einbond Linda S.³,Bemis Debra L.⁴,Weinstein I. Bernard³,Kronenberg Fredi¹,Kennelly Edward J.²

Affiliation:

1. The Richard and Hinda Rosenthal Center for Complementary & Alternative Medicine, Department of Rehabilitation Medicine, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA

2. Department of Biological Science, Lehman College and The Graduate Center, City University of New York, Bronx, NY 10468, USA

3. Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

4. Urology Department, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

Abstract

Previous studies have indicated that black cohosh extracts obtained using different extraction methods can show different chemical profiles and biological activities. In this study, black cohosh plant material was extracted with 18 different solvents. Extraction under different temperatures was compared. Fifteen fractions were also prepared by either stepwise extraction or partition for comparison of chemical profiles and biological activities. All extracts/fractions were qualitatively and quantitatively analyzed for triterpene glycosides and polyphenols by a combined HPLC-PDA and LC-MS method. Most extracts/fractions showed similar chemical profiles for triterpene glycosides, but the amount of the triterpene glycosides varied greatly. The chemical profiles of the polyphenols in the extracts/fractions varied depending upon the type and the composition of the solvent used for the extraction; a certain amount of water in the solvent was necessary for the extraction of polyphenols. Extracts/fractions were selected for anti-cancer and anti-inflammatory activity assays, and the results showed that activities varied with different extracts/fractions. Extraction method is the key to chemical profile and biological activity of black cohosh samples. Researchers should take this into consideration when either designing studies or comparing results among studies, as this may explain some of the results seen in the literature.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0800300925

Reference52 articles.

1. Black Cohosh and Climacteric Symptoms: Growing Knowledge about the Efficacy and Safety

2. Arzneipflanzen in ihren Beziehungen zum weiblichen Genitalsystem

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