Sesquiterpene Lactones from Inula oculus-christi-Reference-Cited by-同舟云学术

Sesquiterpene Lactones from Inula oculus-christi

Published:2010-04 Issue:4 Volume:5 Page:1934578X1000500
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Mosaddegh Mahmoud¹²,Moghadam Maryam Hamzeloo¹²,Ghafari Saeedeh¹²,Naghibi Farzaneh¹²,Ostad Seyed Nasser³,Read Roger W.⁴

Affiliation:

1. Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

2. Faculty of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

3. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

4. School of Chemistry, University of New South Wales, UNSW Sydney 2052 NSW, Australia

Abstract

Inula oculus-christi L. (Compositae) extract was chromatographed and three sesquiterpene lactones ergolide, gaillardin and pulchellin C were isolated. The structures of these compounds were determined by analysis of their spectroscopic data, and their crystal structures were defined using X-ray crystallography; the isolation of ergolide and pulchellin C is reported for the first time from this species. These three compounds were evaluated for their in vitro cytotoxic activity against MDBK, MCF7 and WEHI164 cells; ergolide and gaillardin exhibited lower and significantly different IC50 values compared with pulchellin C ( p<0.001).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1000500402

Reference16 articles.

1. New sesquiterpene lactones from Inula species

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3. Cytotoxic Germacranolides from Inula verbascifolia subsp. methanea

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5. Studies on 1- O -acetylbritannilactone and its derivative, (2- O -butyloxime-3-phenyl)-propionyl-1- O -acetylbritannilactone ester

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