Aramatosides C and D, 2 Previously Undescribed Triterpene Glycosides Isolated From the Roots of Aralia armata-Reference-Cited by-同舟云学术

Aramatosides C and D, 2 Previously Undescribed Triterpene Glycosides Isolated From the Roots of Aralia armata

Published:2021-07 Issue:7 Volume:16 Page:1934578X2110336
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Chuong Nguyen T. Hong¹²,Thuy Van Do T.³,Kim Lien Giang T.⁴,Yen Pham H.⁵⁶,Thuy Hang Dan T.⁵,Nhiem Nguyen X.⁵⁶,Tai Bui H.⁵⁶,Kiem Phan V.⁵⁶^ORCID

Affiliation:

1. Institute of Research and Development, Duy Tan University, Danang, Vietnam.

2. Duy Tan University, Danang, Vietnam.

3. University of Science and Education, The University of Danang, Danang, Vietnam.

4. Institute for Research and Executive Education, The University of Danang, Danang, Vietnam.

5. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

6. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

Abstract

The 2 new oleanane-type triterpene glycosides, 23-hydroxyoleanolic acid-[28- O- β-D-glucopyranosyl]-3- O-{ β-D-glucopyranosyl-(1→2)-[ β-D-glucopyranosyl-(1→3)]- β-D-galactopyranoside}, (1) and oleanolic acid-[28- O- β-D-glucopyranosyl]-3- O-{ β-D-glucopyranosyl-(1→2)-[ β-D-glucopyranosyl-(1→3)]- β-D-galactopyranoside} (2) were isolated from the roots of Aralia armata. Their chemical structures were elucidated by using a combination of high resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1 dimensional (1D), and 2 dimensional (2D) nuclear magnetic resonance spectral data, as well as by comparison with the previous literature. Compounds 1 and 2 displayed weak cytotoxic activity toward KB and HepG2 cell lines with IC50 values of 25.1 ± 1.2 and 23.7 ± 0.9 µM (for 1) and 29.5 ± 1.3 and 23.9 ± 0.7 µM (for 2), respectively, compared to that of the positive control compound, ellipticine (IC50: 1.3 ± 0.1 and 1.6 ± 0.1 µM, respectively) in in vitro assay.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X211033686

Reference9 articles.

1. Herbicidal and Cytotoxic Constituents fromAralia armata(Wall.)Seem.

2. Triterpenoid glucuronide saponins from root bark of aralia armata

3. Araliaarmoside: A New Triterpene Glycoside Isolated From the Leaves of Aralia armata

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