Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus-Reference-Cited by-同舟云学术

Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus

Published:2017-08 Issue:8 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Manse Yoshiaki¹²,Ninomiya Kiyofumi¹³,Okazaki Akane¹,Okada-Nishida Eriko¹²,Imagawa Takahiro¹,Imamura-Mizushima Mami²,Yamano Yuki²,Kaname Kinji²,Nakamura Sho²,Morikawa Toshio¹³

Affiliation:

1. Pharmaceutical Research and Technology Institute, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

2. Kaminomoto Co., Ltd., 3-25 Kumochibashi-dori, 3-chome, Chuo-ku, Kobe, Hyogo 651-0055, Japan

3. Antiaging Center, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

Abstract

A methanol extract from the aerial part of Isodon trichocarpus (Labiatae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells (IC50 = 1.6 μg/mL). From the extract, nine diterpenoids (1–9) and four triterpenoids (10–13) were isolated. Among the isolates, enmein (1, IC50 = 0.22 μM), isodocarpin (2, 0.19 μM), nodosin (4, 0.46 μM), and oridonin (6, 0.90 μM) showed an inhibitory effect without notable cytotoxicity at the effective concentrations. These diterpenoids (1, 2, 4, and 6) inhibited the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA, which could be the mechanism of melanogenesis inhibitory activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200809

Reference27 articles.

1. Authentication and Chemical Study of Isodonis Herba and Isodonis Extracts

2. Diterpenoids of Rabdosia Species

3. Diterpenoids from Isodon species and their biological activities

4. An Investigation of Diterpenes from the Leaves of Rabdosia trichocarpa and Their Antibacterial Activity against Oral Microorganisms.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds;Molecules;2022-07-07

2. Indole Glycosides from Calanthe discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells;Chemical and Pharmaceutical Bulletin;2021-05-01