A New Phenyl Ethyl Glycoside from the Twigs of Acer tegmentosum-Reference-Cited by-同舟云学术

A New Phenyl Ethyl Glycoside from the Twigs of Acer tegmentosum

Published:2015-07 Issue:7 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Park SeonJu¹,Lee Hwa Young²,Nhiem Nguyen Xuan¹³,Lee Taek Hwan¹,Kim Nanyoung¹,Cho Seung Hun⁴,Kim Seung Hyun¹

Affiliation:

1. College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 406–840, Korea

2. Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130–701, Korea

3. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

4. Department of Neuropsychiatry, Hospital of Korean Medicine, Kyung Hee University Medical Center, Seoul, Korea

Abstract

One new phenyl ethyl glycoside, 2-(4-hydroxyphenyl)ethyl- O-α-L-arabinofuranosyl-(1→6)- O-β-D-glucopyranoside (1) and 11 known compounds (2-12) were isolated from the twigs of Acer tegmentum. Compound 6 showed potent anti-neuroinflammatory activity against the LPS-stimulated BV-2 microglial cells with tNO production of 25.0±2.5 μM and TNF-α concentration of 617.6±47.1 pg/mL at 30 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000729

Reference6 articles.

1. Cytotoxic phenolic constituents ofAcer tegmentosum maxim

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3. Phenolic glycosides from the fruit of Strychnos nux-vomica

4. Unprecedented furan-2-carbonyl C-glycosides and phenolic diglycosides from Scleropyrum pentandrum