Macrocyclization Using RCM Reactions. Synthesis of Simple Metacyclophanes and Synthetic Efforts toward Platycarynol, a 15-Membered Aromatic Ether

Abstract

Preparation of 13- to 19-membered carbocycles (metacyclophanes) from 1,3-disubstituted benzene derivatives has been successfully carried out using the RCM reaction, but similar starting materials having diphenyl ether did not cyclize to 15-membered compounds, whose ground state conformations were calculated and discussed. Several attempts to cyclize to form platycarynol are described.