Research Progress on Natural Benzophenanthridine Alkaloids and their Pharmacological Functions: A Review

Author:

Han Na1,Yang Zhiyou1,Liu Zhihui1,Liu Huijing1,Yin Jun1

Affiliation:

1. Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China

Abstract

Benzophenanthridine alkaloids belong to the benzyl isoquinoline family of alkaloids, which are mainly found in Papaveraceae and Rutaceae. To date, over 100 compounds have been isolated from natural herbal medicines which display a variety of pharmacological functions. In this paper, we have summarized the work since 1980 and our own research on benzophenanthridine alkaloids in terms of their chemical structures and distribution, biosynthesis, biotransformation and metabolism, spectral characteristics, pharmacological activities and toxicity. This review lays the foundation for further research into benzophenanthridine alkaloids and their potential applications.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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