Affiliation:
1. Organic Chemistry Division – I, Indian Institute of Chemical Technology, Hyderabad 500007, India
Abstract
Chemical modifications of parthenin, a naturally occurring bioactive sesquiterpenoid, were carried out in regio- and stereoselective manners using various inexpensive reagents to form different natural and unnatural analogues. Reactions including dehydration, reduction, alkylation, addition and hydroxylation have been studied. In some of the analogues, the α-methylene-γ-lactone moiety, which plays a vital role for bioactivity of parthenin, remained intact.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine