An Unusual Bisnor-clerodane Diterpenoid from Polyalthia Simiarum

Author:

Kabir Selina1,Rahman Mohammad S.2,Chowdhury A. M. Sarwaruddin1,Hasan Choudhury M.2,Rashid Mohammad A.2

Affiliation:

1. Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka-1000, Bangladesh

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

Abstract

The stem bark of Polyalthia simiarum has yielded a new bisnor-type clerodane diterpenoid, 2-oxo-14,15-bisnor-3,11 E-kolavadien-13-one (1), and three previously known clerodane derivatives, kolavenic acid (2), 16β-hydroxycleroda-3,13(14) Z-dien-15,16-olide (3), and 16-oxocleroda-3,13(14) E-dien-15-oic acid (4). The structures of these compounds were unambiguously determined by extensive NMR studies as well as by comparison with related compounds. Till now this is the second report of the occurrence of any unusual C-18 clerodane diterpenoid from nature. The crude light petroleum extract and the purified compound 3 demonstrated moderate free radical scavenging activity with IC50 values of 21.5 and 23.5 μg/mL, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference18 articles.

1. Application of flow injection?chemiluminescence to the study of radical scavenging activity in plants

2. KirtikarKR, BasuBD. (1980) Indian Medicinal Plants, Vol. 1, SinghB, SinghMP (Eds), Dehra Dun, India. 72–75.

3. Antimicrobial diterpenes fromPolyalthia longifolia var.pendulla (Annonaceae)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3