4-(Dimethylamino)pyridine as an Efficient Catalyst for One-Pot Synthesis of 1,4-Pyranonaphthoquinone Derivatives viaMicrowave-Assisted Sequential Three Component Reaction in Green Solvent-Reference-Cited by-同舟云学术

4-(Dimethylamino)pyridine as an Efficient Catalyst for One-Pot Synthesis of 1,4-Pyranonaphthoquinone Derivatives viaMicrowave-Assisted Sequential Three Component Reaction in Green Solvent

Published:2021-11 Issue:11 Volume:16 Page:1934578X2110539
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Thanh Nguyen Ha¹²,Phuong Hoang Thi¹,Giang Le Nhat Thuy¹²,Giang Nguyen Thi Quynh¹²,Ha Nguyen Thi Thu¹²,Anh Dang Thi Tuyet¹²,Cuong Vu Duc³,Van Tuyen Nguyen¹²,Van Kiem Phan²⁴^ORCID

Affiliation:

1. Institute of Chemistry, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam

2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam

3. Viet Tri University of Industry, Viet Tri, Phu Tho, Vietnam

4. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam

Abstract

Novel 1,4-pyranonaphthoquinone derivatives were successfully synthesized via the microwave-assisted three-component reaction of 1,4-naphthoquinone, malononitrile, and various arylaldehydes in ethanol in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst, and subsequently evaluated in terms of their antimicrobial and antifungal activities. This synthetic procedure has the notable advantages of environmental friendliness, short reaction time, good yield, and convenient operation.

Funder

Institute of Chemistry

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X211053951

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