Progress on Cassaine-Type Diterpenoid Ester Amines and Amides (Erythrophleum Alkaloids)

Author:

Qu Jing1,Yu Shishan1,Tang Wenzhao1,Liu Yunbao1,Liu Yue1,Liu Jing1

Affiliation:

1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China

Abstract

The structures, spectral characteristics, and bioactivities of 39 natural cassaine-type diterpenoid ester amines and amides (Erythrophleum alkaloids) and 31 synthetic analogues are reviewed. Cassaine-type diterpenoid ester amines and amides, the so called Erythrophleum alkaloids, have the skeleton of cassane-type diterpenoids with a N-containing side chain, and are classified into two groups, ester amines and amides. Cassaine-type diterpenoid ester amines and amides show remarkable inotropic action on the heart, inhibition of Na+/K+-ATPase, cytotoxities, and other major bioactivities. Structural modification of cassaine-type diterpenoid ester amines and amides has been carried out to furnish many derivatives to study the structure-activity relationships.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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