Affiliation:
1. Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai’i at Hilo, Hilo, HI, USA
2. Department of Pharmacy Practice, The Daniel K. Inouye College of Pharmacy, University of Hawai’i at Hilo, Hilo, HI, USA
Abstract
Objective Māmaki tea ( Pipturus albidus) is a native Hawaiian plant species that is best known for its medicinal uses. It is endemic and only grows on the Hawaiian Islands. We evaluated different extraction methods and investigated antioxidant, anticancer, and/or chemopreventive potential of Māmaki tea. Materials and Methods Fresh Māmaki tea leaves were purchased from Hilo Farmers Market on Big Island. The Ferric Reducing Antioxidant Power (FRAP) assay was used to evaluate the antioxidant activities of selected Hawaii-grown teas, fruits, and vegetables. In addition, chemopreventive assays against tumor necrosis factor (TNF)-α-induced nuclear factor kappa B (NF-κB) and nitric oxide (NO) were performed for these Māmaki tea extracts. Cytotoxicity testing was done using in vitro sulforhodamine B (SRB) assay against lung (LU-1) and breast (MCF-7) cancer cell lines. Results Locally grown red vine Māmaki tea exhibited the highest level (40.0 µM/µg) of antioxidants among the tested locally grown fruits, vegetables, and tea. In addition, when tested at 20 µg/mL, the dehydrated Māmaki tea powders (AS-18), brewed from boiling water, showed the highest NF-κB inhibition (75.0%); and the freeze-dried Māmaki leaf powder (AS-1) brewed using room temperature water had the highest inhibitory activity with 55.5% in the nitrite assay. Furthermore, AS-25, the 100% ethanol extract from dehydrated Māmaki tea leaves exhibited the best anticancer activity with the lowest 71.3% survival of breast cancer cells. Conclusions This work stimulates further studies on the biological properties and medicinal uses of Māmaki tea, and raises community and public awareness to promote Māmaki tea.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Reference26 articles.
1. Little ELJr, Skolmen RG. Common forest trees of Hawaii (native and introduced), Agriculture Handbook, Forest Service, U.S. Dept. of Agriculture, 1989; No. 679:104. https://www.fs.fed.us/psw/publications/documents/misc/ah679.pdf.
2. Mamaki tea – Hawaiian Chai. Accessed January 12, 2022. https://www.mauimedicinal.com/collections/mamaki.
3. Mamaki, Kona Coffee and Tea Company. Accessed January 12, 2022. www.konacoffeeandtea.com/blog/mamaki-tea-hawaii.
4. Major Phenolic Acids and Total Antioxidant Activity in Mamaki Leaves, Pipturus albidus
5. Kartika H, Shido J, Nakamoto ST, Li QX, Iwaoka WT. Nutrient and mineral composition of dried mamaki leaves (Pipturus albidus) and infusions. J Food Compos Anal. 2011;24(1):44‐48. doi:10.1016/j.jfca.2010.03.027.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献