Synthetic and Structure-Activity Relationship of Insecticidal Bufadienolides-Reference-Cited by-同舟云学术

Synthetic and Structure-Activity Relationship of Insecticidal Bufadienolides

Published:2014-07 Issue:7 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hidayat Ace Tatang¹,Zainuddin Achmad¹,Dono Danar²,Hermawan Wawan³,Hayashi Hideo⁴,Supratman Unang¹

Affiliation:

1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor 45363, Sumedang, Indonesia

2. Department of Pest and Plant Diseases, Faculty of Agriculture, Padjadjaran University, Jatinangor 45363, Sumedang, Indonesia

3. Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor 45363, Sumedang, Indonesia

4. Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–1 Gakuen-cho, Sakai, Osaka 599–8531, Japan

Abstract

A new synthetic analog of bufadienolide, methyl isobryophyllinate A (1), and a known synthetic analog, methyl isobersaldegenate-1,3,5-orthoacetate (2), were obtained by methanolysis of bryophyllin A (3) and bersaldegenin-1,3,5-orthoacetate (5) in basic solution. Structure-insecticidal activity relationship studies revealed both orthoacetate and α-pyrone moieties seemed to be essential structural elements for exhibiting insecticidal activity, whereas oxygenated substituents in the C ring enhanced the insecticidal activity against the third instar larvae of silkworm (Bombyx mori).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900710

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4. Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure–activity relationships

5. Structure–cytotoxic activity relationship for the toad poison bufadienolides