Affiliation:
1. Gitam Institute of Pharmacy, Gitam University, Rushikonda, Visakhapatnam-530 045, India
2. Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany
3. A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003 (A.P.), India
4. Institute for Inorganic and Applied Chemistry, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany
Abstract
Chemical re-examination of the roots of T. calophylla led to the isolation of four isoflavones, namely 2′,4′,5-trihydroxy-6,7-(2″,2″-dimethylchromene)-8-γ,γ-dimethylallylisoflavone (1a, auriculatin), 2′,5-dihydroxy-6,7-(2″,2″-dimethylchromene)-4′-γ,γ-dimethylallyloxyisoflavone (2a, isoauriculatin), 3′,4′,5-trihy-droxy-6,7-(2″,2″-dimethylchromene)-8-γ,γ-dimethylallylisoflavone (1b, auriculasin), and 3′,5-dihydroxy-6,7-(2″,2″-dimethylchromene)-4′-γ,γ-dimethylallyl-oxyisoflavone (2b, isoauriculasin). Auriculasin and isoauriculasin are reported for the first time with full NMR assignments. All metabolites were fully characterized by 1D and 2D NMR techniques including COSY, HSQC, HMBC experiments, mass spectra and in part on the basis of X-ray diffraction. Accurate ‘invariom’ refinements with aspherical scattering factors were carried out for 1a, 1b and 2a.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Cited by
1 articles.
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