Gymsyloside F and Gymsyloside G, Two New Pregnane Glycosides From the Leaves of Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities

Author:

Yen Pham Hai12,Hai Yen Duong Thi1,Viet Thanh Nguyen Thi3,Hung Nguyen Anh4,Bang Ngo Anh1,Tai Bui Huu12,Nhiem Nguyen Xuan12,Kiem Phan Van12

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

3. School of Chemical Engineering, Hanoi University of Science and Technology, Hanoi, Vietnam

4. Faculty of Chemistry, Hanoi Pedagogical University, Vinhphuc, Vietnam

Abstract

Two new pregnane glycosides were isolated from the leaves of Gymnema sylvestre (Retz.) R.Br. ex Sm. Their chemical structures were determined as (20 S)−12 β-tigloyloxy-5 α-hydroperoxy-3 β,8 β,14 β,17 β,20-pentahydroxypregn-6-ene 3- O-β-D-glucopyranosyl-(1→4)‐6-deoxy-3- O-methyl- β-D-allopyranosyl-(1→4)- β-D-oleandropyranosyl-(1→4)- β-D-cymaropyranosyl-(1→4)- β-D-cymaropyranoside (1) and (20 S)−12 β-benzoyloxy-5 α-hydroperoxy-3 β,8 β,14 β,17 β,20-pentahydroxypregn-6-ene 3- O-β-D-glucopyranosyl-(1→4)‐6-deoxy-3- O-methyl- β-D-allopyranosyl-(1→4)- β-D-oleandropyranosyl-(1→4)- β-D-cymaropyranosyl-(1→4)- β-D-cymaropyranoside (2) on the basis of the extensive spectroscopic methods, including 1D, 2D NMR, HRESIMS, and in comparison with the reported data. At the concentration of 200 µM, compounds 1 and 2 showed moderate anti α-glucosidase and α-amylase activities with inhibitory percentage of 31.1 ± 1.2 and 42.3 ± 1.7% (for α-glucosidase), and 27.8 ± 1.3 and 34.5 ± 1.5% (for α-amylase), respectively.

Funder

vietnam academy of science and technology

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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