Isolation of a New Homomonoterpene from Madhuca Pasquieri and Effect of Isolated Compounds on NO Production-Reference-Cited by-同舟云学术

Isolation of a New Homomonoterpene from Madhuca Pasquieri and Effect of Isolated Compounds on NO Production

Published:2016-06 Issue:6 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hoang Le Son¹,Tran Manh Hung¹,Nguyen Van Thu¹,Ngo Quynh Mai Thi¹,Lee Joo-Sang¹,Rho Seong-Soo²,Kim Jeong Ah³,Lee Jeong-Hyung⁴,Woo Mi Hee¹,Min Byung Sun¹

Affiliation:

1. College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Korea

2. Korean Medicine of College, DaeguHaany University, Daegu 42158, Korea

3. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701, Korea

4. College of Natural Sciences, Kangwon National University, Gangwon-do 200-701, Korea

Abstract

A new homomonoterpene, l,3,3-trimethyl-7-oxabicyclo[3.1.1]hexa-9-en-10-oic acid, named madhusic acid A (1), together with ten known compounds (2-11) were isolated from the methanolic extract of the dried leaves of Madhuca pasquieri (Dubard) H. J. Lam. The structure of the new compound was elucidated on the basis of ID, 2D NMR (COSY, HMQC, and HMBC) and mass spectral analyses. We examined the effects of the isolated compounds against LPS-induced NO production in macrophage RAW264.7 cells and compound 2 showed effective activity with an IC50 value of 14.5 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100608

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1. Four new species of Madhuca (Sapotaceae) from Thailand

2. Pyrrolizidine alkaloids from Liparis nervosa with inhibitory activities against LPS-induced NO production in RAW264.7 macrophages

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