New Antiplasmodial Diterpenes from Gutierrezia Sarothrae-Reference-Cited by-同舟云学术

New Antiplasmodial Diterpenes from Gutierrezia Sarothrae

Published:2016-06 Issue:6 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Su Qingxi¹,Dalal Seema²,Goetz Michael³,Cassera Maria B.²,Kingston David G. L¹

Affiliation:

1. Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA

2. Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA

3. Natural Products Discovery Institute, Doylestown, PA, 18902, USA

Abstract

Bioassay guided fractionation of the MeOH extract of the plant Gutierrezia sarothrae (Asteraceae) using an assay for antiplasmodial activity against the drug-resistant Dd2 strain of Plasmodium falciparum led to the isolation of the two new diterpenes 3α-angeloyloxy-15-hydroxylabda-7,13-dien-16,15-olid-18-oic acid (1) and 3α-angeloyloxy-15-methoxylabda-7,13-dien-16,15-olid-18-oic acid (2). The structures of 1 and 2 were elucidated by interpretation of ID and 2D NMR spectroscopic data, mass spectrometry, and comparison with the data of related compounds reported in the literature. Compound 1 exhibited moderate antiplasmodial activity with an IC50 values of 10.4 ± 4.3 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100605

Reference14 articles.

1. Remote Sensing of Broom Snakeweed (Gutierrezia sarothrae) and Spiny Aster (Aster spinosus)

2. Volatile Composition ofGutierrezia sarothrae(Broom Snakeweed) as Determined by Steam Distillation and Solid Phase Microextraction

3. Monoterpenes of Gutierrezia sarothrae