Affiliation:
1. Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, 310013,P.R. China
Abstract
Two new 13, 14/14, 15-disecopregnane-type skeleton C21 steroidal aglycones, neocynapanogenin G (1) and neocynapanogenin H (2), were isolated from the hydrolyzed extract of the CHC13 soluble extract of the roots of Cynanchun paniculatum. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including ID and 2D NMR spectroscopy. Compound 1 displayed significant inhibition of the Hedgehog signaling pathway in vitro.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine