In Vivo Efficacy of TXCB, a Vietnamese Herbal Medicine Prescription, on Seminal Quality, Serum Testosterone, and Malondialdehyde Concentration in Rabbits

Author:

Thang Vu Ngoc1,Tuan Nguyen Thanh Ha2,Binh Pham Quoc3,Phuong Nguyen Minh4,Tuyen Thai Danh5,Thuy Doan Minh6ORCID,Tran Manh Hung7ORCID,Ngan Nguyen Hoang1

Affiliation:

1. Department of Pharmacology, Vietnam Military Medical University, Hanoi, Vietnam

2. Traditional Medicine Department, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam

3. Department of Theoretical Traditional Medicine, Vietnam University of Traditional Medicine, Hanoi, Vietnam

4. Department of Military Occupational Medicine, Vietnam Military Medical University, Hanoi, Vietnam

5. Department of Hematology and Blood Transfution, Military Hospital 103, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam

6. Department of General External Medicine, Vietnam University of Traditional Medicine, Hanoi, Vietnam

7. Faculty of Pharmacy, Dong A University, Hai Chau, Da Nang, Vietnam

Abstract

The efficacy of Truong Xuan Cao Bang (TXCB), a Vietnamese herbal medicine prescription, on the quality of semen, serum testosterone (TES), and malondialdehyde (MDA) concentrations in rabbits whose reproductive ability were impaired by fluconazole was investigated. Mature male rabbits were randomly assigned into control (G1), fluconazole (G2), fluconazole and 180 mg/kg/day (G3), and 360 mg/kg/day TXCB (G4) groups. The reaction time (RT), ejaculate volume (EV), sperm concentration (SC), total sperm output (TSO), total sperm motility (TSM), progressive sperm motility (PSM), nonprogressive sperm motility (NPSM), sperm immobility (SIM), dead sperm (DS), and abnormal sperm (AS) levels were determined after TXCB administration. After 60 days, G3 showed a significant increase in serum TES and a significant decrease in the concentrations of serum MDA (SMDA) and seminal plasma MDA (SPMDA) compared with G1, in addition to increase in EV, SC, TSO, TSM, PSM, and serum TES, and decrease in RT, SIM, DS, AS, SMDA, and SPMDA compared with G2. G4 showed a steep rise in EV, SC, and serum TES and a downturn in DS, SMDA, and SPMDA compared with G1, and, compared with G2, a significant increase in EV, SC, TSO, TSM, PSM, and serum TES and a significant decrease in RT, SIM, DS, AS, SMDA, and SPMDA. Taken together, TXCB rehabilitates and simultaneously enhances spermatogenesis in rabbits whose reproductive ability was impaired by fluconazole.

Funder

Cao Bang Province, Vietnam

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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