Polyhydroxy Sterols Isolated from the Red Sea Soft Coral Lobophytum crassum and their Cytotoxic Activity-Reference-Cited by-同舟云学术

Polyhydroxy Sterols Isolated from the Red Sea Soft Coral Lobophytum crassum and their Cytotoxic Activity

Published:2017-02 Issue:2 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Aboutabl Elsayed A.¹,Selim Nabil M.¹,Azzam Shadia M¹,Michel Camilia G.¹,Hegazy Mohamed F.²,Ali Abdelhamid M.³,Hussein Ahmed A.⁴

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, El-Kasr El-Einy st. Cairo, 11432, Egypt

2. Phytochemistry department, National Research Center, El-behooth st. Giza, Egypt

3. National Institute of Oceanography and Fisheries, Attaka P.O. Box, 182, Suez, Egypt

4. Department of Chemistry, Cape Peninsula University of Technology, Bellville Campus, PO Box 1906, Bellville 7535, South Africa

Abstract

One new (1) together with four known sterols (2 - 5) and a sesquiterpene (6) were isolated from a polar extract of the Red Sea soft coral Lobophytum crassum. The compounds were identified as 24-methylenecholest-5-ene-1α,3 1α,11α-triol 1-acetate (1), 24-methylenecholest-5-ene-1α,3β,11α-triol (2), 24-methylenecholest-5-ene-3β-ol (3), 24-methylenecholestane-1α,3β,5a,6P,1-pentol (4), 24-methylenecholestane-3β,5α,6β-triol (5) and alismoxide (6) based on extensive NMR analysis. The cytotoxicity of compounds 1 - 6 was evaluated in vitro using three human cancer cell lines viz., HepG2, Hep-2 and HCT-116. Compound 1 showed selective cytotoxic activity against HepG2, while 3 exhibited cytotoxicity against all tested cell lines.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200223

Reference27 articles.

1. Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum

2. Further cembranoid derivatives from the Red Sea soft corals Alcyonium flaccidum and Lobophytum crassum

3. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

4. Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum

5. Cytotoxic and Anti-inflammatory Cembranoids from the Soft Coral Lobophytum crassum

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