New Cyclopentyl Fatty Acid and Cyanohydrin Glycosides from Fruits of Hydnocarpus hainanensis-Reference-Cited by-同舟云学术

New Cyclopentyl Fatty Acid and Cyanohydrin Glycosides from Fruits of Hydnocarpus hainanensis

Published:2017-02 Issue:2 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Nguyen Thanh Tra¹²,Truong Bich Ngan¹,Mai Huong Doan Thi¹,Litaudon Marc³,Nguyen Van Hung¹,Thi Thao Do⁴,Tran Van Hieu¹,Tran Dang Thach⁵,Chau Van Minh¹,Pham Van Cuong¹

Affiliation:

1. Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

2. Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

3. Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Univ. Paris-Sud, 91198, Gif-sur-Yvette, France

4. Institute of Biotechnology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

5. Industrial University of Vinh, 26 Nguyen Thai Hoc, Vinh, Nghe-An, Vietnam

Abstract

Three new compounds, hydnohainanic acid (1), and hydnohainanin A (2) and B (3) were isolated from the fruits of Hydnocarpus hainanensis (Achariaceae). Their structures were determined by spectroscopic analysis, including 2D NMR, and MS. Compounds 1-3 were evaluated for their cytotoxic activity against the KB cell line. Compound 1 had a moderate cytotoxicity with an IC50 value of 32.5 μg/mL, while the two remaining compounds did not exhibit inhibition, even at a concentration of 128 μg/mL.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200228

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