Two New Steroidal Alkaloid Saponins from the Whole Plants of Solanum nigrum-Reference-Cited by-同舟云学术

Two New Steroidal Alkaloid Saponins from the Whole Plants of Solanum nigrum

Published:2018-11 Issue:11 Volume:13 Page:1934578X1801301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Tai Bui Huu¹,Van Doan Vu¹,Yen Pham Hai¹,Nhiem Nguyen Xuan¹,Cuc Nguyen Thi¹,Trang Do Thi¹,Hang Dan Thi Thuy¹,Dung Duong Thi¹,Yen Duong Thi Hai¹,Quang Tran Hong¹,Dang Nguyen Hai¹,Mai Nguyen Thi²,Van Minh Chau¹,Van Kiem Phan¹³

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. University of Transport and Communications, 3 Cau Giay, Dong Da, Hanoi, Viet Nam

3. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Abstract

Two new steroidal alkaloid saponins, solanigrosides Q and R (1 and 2), together with four known compounds khasianine (3), solamargine (4), solasonine (5), and soladulcoside A (6) were isolated from the whole plants of Solanum nigrum. The structures of new compounds (1 and 2) were determined by interpretation of HR-ESI-MS, 1D and 2D NMR spectra, and chemical transformation. Compound 4 exhibited potent cytotoxic activity against MDA-MB-231, A549, Hep3B, PC3 human cancer cell lines with IC50 values of 1.86 ± 0.45, 2.24 ± 0.15, 0.78 ± 0.11, 5.13 ± 1.34 μM, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801301111

Reference19 articles.

1. Potential Anti-inflammatory Steroidal Saponins from the Berries of Solanum nigrum L. (European Black Nightshade)

2. Bioactive steroidal alkaloids from the fruits of Solanum nigrum

3. Anti-inflammatory steroidal glycosides from the berries of Solanum nigrum L. (European black nightshade)

4. Steroidal Saponins from Solanum nigrum

5. Steroidal Oligoglycosides from Solanum nigrum.

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