Lanostane-type Triterpenoids from Ganoderma lucidum and G. multipileum Fruiting Bodies-Reference-Cited by-同舟云学术

Lanostane-type Triterpenoids from Ganoderma lucidum and G. multipileum Fruiting Bodies

Published:2018-11 Issue:11 Volume:13 Page:1934578X1801301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Binh Pham Thanh¹²,Thao Nguyen Phuong¹,Luyen Nguyen Thi³,Trang Duong Thu¹,Binh Phung Thi Xuan⁴,Nguyen Nguyen Phuong Dai⁵,Hiep Nguyen Tuan⁶,Dang Nguyen Hai¹,Tri Tran Manh²,Dat Nguyen Tien³

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. Faculty of Chemistry, VNU University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Vietnam

3. Center for Research and Technology Transfer, VAST, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

4. Dien Luc University, 235 Hoang Quoc Viet, Hanoi, Vietnam

5. Department of Biology, University of Tay Nguyen, 567 Le Duan, Dac Lac City, Vietnam

6. National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam

Abstract

Sixteen lanostane-type triterpeneoids were isolated from the fruiting bodies of wild Ganoderma lucidum and G. multipileum. The new structures 3 S,24 S,25,26-tetrahydroxy-5α-lanost-8-en-11-one (1) and ganodermanondiol 24,25-acetonide (10) were elucidated by means of spectroscopic data and Mosher's experiments. Lanosta-7,9(11)-dien-3β-ol (9) strongly inhibited α-glucosidase with the IC50 values of 198.8 μM in compared with acarbose (IC50 712.4 μM).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801301107

Reference11 articles.

1. A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

2. Secondary metabolites from Ganoderma

3. Two New Lanostanoid Triterpenes from the Fruit Body of Ganoderma lucidum-the Major Component of SunRecome®

4. Cytotoxicity of 9,11-Dehydroergosterol Peroxide Isolated from Ganoderma Lucidum and its Target-related Proteins

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