Determination of the Solubility, Dissolution Enthalpy, and Entropy of Icariin in Acetone, Acetoacetate, Chloroform, and Light Petroleum-Reference-Cited by-同舟云学术

Determination of the Solubility, Dissolution Enthalpy, and Entropy of Icariin in Acetone, Acetoacetate, Chloroform, and Light Petroleum

Published:2020-11 Issue:11 Volume:15 Page:1934578X2097149
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Xie Jiao¹^ORCID,Zhang Kanghuai¹,Wang Haitao¹,Yang Xin¹,Mao Wenbin²,Liu Chenwei¹,Wang Na¹^ORCID

Affiliation:

1. Department of Pharmacy, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, PR China

2. Outpatient Management Office, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, PR China

Abstract

The solubility of icariin in acetone, acetoacetate, chloroform, and light petroleum in the 283.2‐318.2 K range was measured by ultraviolet-visible spectrophotometry. As the temperature increased, the solubility of icariin in the 4 solvents gradually increased. The solubility data correlated with the modified Apelblat equation. The dissolution enthalpy and entropy of icariin were determined using van’t Hoff plots. The dissolution enthalpy and entropy of icariin in the 4 solvents increases as acetone >acetoacetate >chloroform >light petroleum, which can be explained by the difference of the polarity indices between them. The polarity indices of the solvents affect the solubility behavior.

Funder

the clinical research award of the Second Affiliated Hospital of Xi’an Jiaotong University

Natural Science Foundation of Shaanxi Province

Key Research and Development Program of Shaanxi Province

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20971491

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