Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids-Reference-Cited by-同舟云学术

Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids

Published:2016-01 Issue:1 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Khusnutdinova El'mira F.¹,Smirnova Irina E.¹,Giniyatullina Gul'nara V.¹,Medvedeva Natal'ya I.¹,Yamansarov Emil Yu.¹,Kazakov Dmitri V.¹,Kazakova Oxana B.¹,Linh Pham T.²,Viet Do Quoc²,Huong DoThi Thu²

Affiliation:

1. Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation

2. Institute of Chemistry Vietnamese Academy of Sciences, 18 Hoang Quoc Viet St., CauGiay Dist., Hanoi, Vietnam

Abstract

A variety of new and earlier synthesized lupane, oleanane, ursane and dammarane triterpenoids have been investigated for their inhibitory activity against α-glucosidase. 2,3-Indole-21β-acetyl-20β,28-epoxy-18α,19βH-ursane and 3-oxo-3A-homo-3a-aza-20( S)-hydroxydammar-24(25)-ene were synthesized for the first time. The compounds 3, 4, 8–11 and 14 demonstrated strong in vitro inhibitory activity towards α-glucosidase with IC50 values of 37.5–115.1 μM. 3-Deoxy-3a-homo-3a-aza-28-cinnamoyloxy-20(29)-lupene, with an IC50 of 6.67 μM was 60-fold more active than the market drug acarbose.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100112

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