Steroidal Glucosides from the Rhizomes of Tacca Chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells-Reference-Cited by-同舟云学术

Steroidal Glucosides from the Rhizomes of Tacca Chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells

Published:2016-01 Issue:1 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Yen Pham Hai¹,Chi Vu Thi Quynh¹,Kim Dong-Cheol²,Ko Wonmin²,Oh Hyuncheol²,Kim Youn-Chul²,Dung Duong Thi¹,Thanh Nguyen Thi Viet³,Quang Tran Hong¹²,Ngan Nguyen Thi Thanh²,Nhiem Nguyen Xuan¹,Anh Hoang Le Tuan¹,Van Minh Chau¹,Van Kiem Phan¹

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea

3. School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Hanoi, Vietnam

Abstract

Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4), chantriolide C (5), and (25 S)-spirost-5-en-3-ol 3- O-α-L-rhamnopyranosyl-(1→2)- O-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by 1D and 2D NMR spectroscopic and HR-ESI-MS data, as well as by comparison with reported data. Compounds 1 and 2 were found to show strong inhibitory NO effect in BV2 cells, with IC50 values of 12.45 and 59.03 μM, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100115

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