Isolation, Structural Characterization and Neurotrophic Activity of Alkylamides from Zanthoxylum bungeanum-Reference-Cited by-同舟云学术

Isolation, Structural Characterization and Neurotrophic Activity of Alkylamides from Zanthoxylum bungeanum

Published:2017-07 Issue:7 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Wang Yuan¹²,Liao Zhong-Bin¹,Cao Rong¹,Li He¹,Wei An-Zhi³,Gao Jin-Ming¹

Affiliation:

1. Shaanxi Key Laboratory of Natural Products & Chemical Biology, Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, People's Republic of China

2. College of Life Science, Northwest A&F University, Yangling 712100, People's Republic of China

3. College of Forestry, Northwest A&F University, Yangling 712100, People's Republic of China

Abstract

Two new fatty acid amides, zanthoamides E (1) and F (2), were isolated from the pericarps of Zanthoxylum bungeanum. The structures of the two sanshool compounds were elucidated by analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). All isolated compounds (1–9) were evaluated for nerve growth factor (NGF)-potentiating activity using PC-12 cells, and the results indicated that compound 8 (tetrahydrobungeanool) showed the strongest neurotrophic activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200730

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