Essential Oils from two Lantana species with Antimycobacterial Activity-Reference-Cited by-同舟云学术

Essential Oils from two Lantana species with Antimycobacterial Activity

Published:2009-12 Issue:12 Volume:4 Page:1934578X0900401
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

de Santana Julião Lisieux¹,Bizzo Humberto R.²,Souza Andressa M.²,Lourenço Maria Cristina S.³,Silva Pedro Eduardo A.⁴,Tavares Eliana S.¹,Rastrelli Luca⁵,Leitão Suzana Guimarães⁶

Affiliation:

1. Programa de Biotecnologia Vegetal, Universidade Federal do Rio de Janeiro, CCS, Bl. K. 2° andar, Rio de Janeiro, RJ, Brazil

2. Embrapa Agroindústria de Alimentos, Avenida das Américas 29501, 23020-470 Rio de Janeiro-RJ, Brazil

3. Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz Laboratório de Bacteriologia eBioensaios em Micobactérias, Plataforma de Bioensaios II, FIOCRUZ, 21045-900, Rio de Janeiro, Brazil

4. Universidade Federal do Rio Grande, FURG, Laboratório de Micobactérias, Rio Grande, RS, Brazil

5. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Fisciano (SA), Italy

6. Universidade Federal do Rio de Janeiro, Faculdade de Farmácia, Departamento de Produtos Naturais e Alimentos, CCS, Bl. A, 2oandar, Ilha do Fundão, 21.941-590, Rio de Janeiro, RJ, Brazil

Abstract

Lantana trifolia L. and L. fucata Lindl. are two Brazilian species used in folk medicine for the treatment of respiratory disorders. The composition of the essential oils from the leaves was investigated, as well as their in vitro activity against Mycobacterium tuberculosis. L. trifolia yielded an oil (0.2%) rich in sesquiterpenes. The major substances found were germacrene D (45.1%), (E)-caryophyllene (12.8%), bicyclogermacrene (12.7%) and α-humulene (4.4%). Sesquiterpenes were also the main components of the oil of L. fucata (0.3% yield), the principal ones being β-elemene (27.1%), germacrene D (11.6%), (E)-caryophyllene (7.7%), valencene (5.7%) and germacrene A (4.6%). Both oils exhibited in vitro antimycobacterial activity by the MABA assay with MICs of 80 μg/mL for L. trifolia and 100 μg/mL for L. fucata.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0900401224

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