New Neo-Lignan From Acanthopanax senticosus and the Cytotoxic Effects on Human Cancer Cell Lines

Abstract

A new neo-lignan named (7ʹ S,8ʹ R)-4ʹ,5ʹ,9ʹ-trihydroxy-5-methoxy-4,8ʹ-oxyneolign-7-en-9-al (1), together with 5 known compounds (2-6) were isolated from the ethylacetate-soluble extract of Acanthopanax senticosus. The structure of new neo-lignan was elucidated with spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro cytotoxicity against 4 human cancer lines including HepG2, A549, Hela, and MCF-7. Among them, compounds 1 and 3 showed the potent antiproliferative activities against the HepG2 cancer cells with half-maximal inhibitory concentration (IC50) values of 9.8 ± 1.6 and 15.0 ± 1.1 μM, respectively. In addition, compound 6 exhibited moderate inhibitory activity on MCF-7 cancer cells with an IC50 value of 18.3 ± 1.5 μM.