Semisynthesis of Justicidone and a 1,2-Quinone Lignan. Cytotoxic Activity of Some Natural and Synthetic Lignans-Reference-Cited by-同舟云学术

Semisynthesis of Justicidone and a 1,2-Quinone Lignan. Cytotoxic Activity of Some Natural and Synthetic Lignans

Published:2009-02 Issue:2 Volume:4 Page:1934578X0900400
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Boluda Carlos J.¹,Trujillo Juan M.²,Pérez José A.¹,López Hermelo¹,Aragón Zulma¹,Díaz Raquel G.²

Affiliation:

1. Instituto Universitario de Bioorgánica “Antonio González”, Universidad de La Laguna, Avda. Astrofísico F. Sánchez, 2, 38206 La Laguna, Tenerife, Canary Islands, Spain

2. Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Canary Islands, Spain

Abstract

The dioxo-lignans of the arylnaphthalene-type named justicidone (2) and elenodione (3) were obtained from elenoside (1) through a short and efficient semisynthetic process. Justicidone (2), one of its synthetic precursors, 4-(benzo[d][1,3]dioxol-5-yl)-5,6,8-trimethoxy-3a,4-dihydronaphtho[2,3-c]furan-1(3H)-one (9), and the aglycone of elenoside (5) showed cytotoxic activity towards the HL-60 cell line (IC50 = 7.25 μM, 5.41 μM and 2.06 μM, respectively).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0900400214

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