A Pyranochalcone and Prenylflavanones from Tephrosia pulcherrima (Baker) Drumm

Author:

Ganapaty Seru1,Srilakshmi Guttula V. K.1,Pannakal Steve T.1,Laatsch Hartmut2

Affiliation:

1. Pharmacognosy and Phytochemistry Division, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003 Andhra Pradesh, India

2. Institute for Organic Chemistry, University of Gottingen, Tammannstrasse 2, D-37077 Gottinggen, Germany

Abstract

A new 2′,6′-dimethoxy-4′,5′-(2″,2″-dimethyl)-pyranochalcone (1) and three known flavanones, namely 5-hydroxy-7-methoxy-8-(3,3-dimethylallyl)-flavanone (methyl glabranin) (2), 5,7-dimethoxy-8-(3,3-dimethylallyl)-flavanone (candinone) (3) and 5- O-methyl obovatin (pongachin) (4), have been isolated from the chloroform extract of the roots of Tephrosia pulcherrima. The flavonoids were fully characterized by detailed 1D- and 2D-NMR spectroscopic investigations. The pyranochalcone 1 showed significant antimicrobial activity when tested against a series of micro-organisms.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference18 articles.

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2. WillisJC. (1973) Dictionary of Flowering Plants and Ferns, University Press, Cambridge, 1135.

3. ChandraM. (1976) (Ed.) The Wealth of India, Publications and Information Directorate. CSIR, New Delhi, 151–157.

4. WattMJ, Breyer-BrandwijkMG. (1962) The Medicinal and Poisonous Plants of Southern and Eastern Africa, 1st ed. Livingstone, London, 653–663.

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